The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2022

Filed:

Sep. 25, 2020
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Jennifer A. Doudna, Berkeley, CA (US);

David Burstein, Berkeley, CA (US);

Janice S. Chen, Berkeley, CA (US);

Lucas B. Harrington, Berkeley, CA (US);

David Paez-Espino, Walnut Creek, CA (US);

Jillian F. Banfield, Berkeley, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6809 (2018.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C07K 2319/09 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract

Provided are compositions and methods that include one or more of: (1) a 'CasZ' protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a 'CasZ trancRNA'), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same).


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