The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Feb. 16, 2017
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Tae-Eun Park, Boston, MA (US);
Anna Herland, Brookline, MA (US);
Edward Anthony Fitzgerald, Boston, MA (US);
Donald Elliot Ingber, Boston, MA (US);
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12M 3/06 (2006.01); C12N 5/00 (2006.01); G01N 27/403 (2006.01);
U.S. Cl.
CPC ...
C12N 5/069 (2013.01); C12M 23/16 (2013.01); C12N 5/0062 (2013.01); C12N 5/0068 (2013.01); G01N 27/403 (2013.01); C12N 2500/02 (2013.01); C12N 2502/081 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2533/90 (2013.01);
Abstract
The invention relates to a method of creating a human blood-brain barrier (BBB) model from the differentiation of human pluripotent stem cells (hPSCs), wherein the BBB exhibits sustained transendothelial electrical resistances (TEER) over 2000 Ω·cmfor at least 3 days after seeding.