The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2022

Filed:

Nov. 10, 2017
Applicants:

Daniel Cua, Boulder Creek, CA (US);

Holly Cherwinski, Boulder Creek, CA (US);

Adele Wang, San Mateo, CA (US);

Yi Chen, San Jose, CA (US);

Barbara Joyce-shaikh, San Jose, CA (US);

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Daniel Cua, Boulder Creek, CA (US);

Holly Cherwinski, Boulder Creek, CA (US);

Adele Wang, San Mateo, CA (US);

Yi Chen, San Jose, CA (US);

Barbara Joyce-Shaikh, San Jose, CA (US);

Assignee:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 35/00 (2006.01); G01N 33/542 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61P 35/00 (2018.01); G01N 33/542 (2013.01); A61K 2039/505 (2013.01); C07K 2317/32 (2013.01); C07K 2317/76 (2013.01);
Abstract

The present invention provides antibodies and antigen-binding fragments thereof that bind ILT3, ILT3 ligand (i.e., PI16) or a complex between ILT3 and the ILT3 ligand. Methods for determining whether ILT3 and the ILT3 ligand bind together or whether a substance agonizes or antagonizes such binding are also provided.


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