The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Jan. 24, 2017
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Jayme Franklin, South San Francisco, CA (US);
Xin Xin Lin, South San Francisco, CA (US);
Jeffrey Gorrell, South San Francisco, CA (US);
Timothy Tully, South San Francisco, CA (US);
Matthew Hutchinson, South San Francisco, CA (US);
Charity Tucker Bechtel, South San Francisco, CA (US);
Assignee:
GENENTECH, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/07 (2006.01); C07K 16/28 (2006.01); C07K 1/113 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 38/07 (2013.01); A61K 47/65 (2017.08); A61K 47/6803 (2017.08); A61K 47/6811 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); C07K 1/1133 (2013.01);
Abstract
The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.