The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Aug. 16, 2019
Denali Therapeutics Inc., South San Francisco, CA (US);
Xiaocheng Chen, South San Francisco, CA (US);
Mark S. Dennis, South San Francisco, CA (US);
Lesley Ann Kane, South San Francisco, CA (US);
Do Jin Kim, South San Francisco, CA (US);
Joseph W. Lewcock, South San Francisco, CA (US);
Suresh Poda, South San Francisco, CA (US);
Rishi Rakhit, South San Francisco, CA (US);
Rinkan Shukla, South San Francisco, CA (US);
Adam P. Silverman, South San Francisco, CA (US);
Denali Therapeutics Inc., South San Francisco, CA (US);
Abstract
In one aspect, antibodies that specifically bind to a human Tau protein are provided. In some embodiments, an anti-Tau antibody recognizes an epitope within residues 111-125 of full-length human Tau, an epitope within residues 251-270 and/or residues 346-360 of full-length human Tau, or an epitope within residues 186-205 of full-length human Tau. In some embodiments, an anti-Tau antibody specifically binds to phosphorylated human Tau, unphosphorylated human Tau, and/or multiple splice isoforms of human Tau. An anti-Tau antibody disclosed herein may also include one or two modified Fc polypeptides.