The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Apr. 19, 2021
Applicant:
Regents of the University of Minnesota, Minneapolis, MN (US);
Inventors:
Bruce Kenneth Walcheck, Lino Lakes, MN (US);
Dan Samuel Kaufman, Woodbury, MN (US);
Jianming Wu, Plymouth, MN (US);
Yawu Jing, Shoreview, MN (US);
Zhenya Ni, Edina, MN (US);
Assignee:
Regents of the University of Minnesota, Minneapolis, MN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/63 (2006.01); C07K 17/00 (2006.01); A61K 48/00 (2006.01); C07K 14/735 (2006.01); C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); C07K 16/32 (2006.01); C12N 5/0787 (2010.01); C12N 5/0786 (2010.01); A01K 67/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70535 (2013.01); A61K 35/17 (2013.01); A61K 38/1774 (2013.01); A61K 39/39558 (2013.01); C07K 16/32 (2013.01); C12N 5/0642 (2013.01); C12N 5/0645 (2013.01); C12N 5/0646 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C12N 2501/599 (2013.01); C12N 2510/00 (2013.01);
Abstract
This disclosure describes, generally, a modified form of CD16, genetically-modified cells that express the modified CD16, and methods that involve the genetically-modified cells. The modified form of CD16 can exhibit increased anti-tumor and/or anti-viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.