The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Oct. 29, 2015
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Zheng-Yi Chen, Somerville, MA (US);
David R. Liu, Cambridge, MA (US);
Margie Li, Cambridge, MA (US);
David B. Thompson, Cambridge, MA (US);
John Zuris, Cambridge, MA (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.