The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Jan. 21, 2019
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventor:
Hasane Ratni, Habsheim, FR;
Assignee:
Hoffmann-La Roche, Inc., Little Falls, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01);
Abstract
The present invention relates to a compound of formula (I) wherein Ar is (II) or (II); R is CHor OCH; or a pharmaceutically acceptable acid addition salt or a corresponding enantiomer thereof. The compounds are modulators of γ-secretase (A β42) and may be useful for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.