The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2022

Filed:

Aug. 24, 2018
Applicants:

Academia Sinica, Taipei, TW;

Kaohsiung Medical University, Kaohsiung, TW;

Inventors:

Steven R Roffler, Taipei, TW;

Tian-Lu Cheng, Kaohsiung, TW;

Chien-Han Kao, Kaohsiung, TW;

Bing-Mae Chen, Taipei, TW;

Yu-Cheng Su, Taipei, TW;

Hsin-Yi Tung, Taipei, TW;

Kuo-Hsiang Chuang, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/26 (2006.01); A61K 47/14 (2017.01); A61K 47/69 (2017.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6897 (2017.08); A61K 39/39558 (2013.01); A61K 47/14 (2013.01); A61K 47/6929 (2017.08); A61P 35/00 (2018.01); C07K 16/26 (2013.01); C07K 16/2863 (2013.01); C07K 16/2869 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/32 (2013.01); A61K 45/06 (2013.01); A61K 2300/00 (2013.01);
Abstract

Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.


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