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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11369669 B1

PDFFull Text
Date of Patent:
Jun. 28, 2022

Filed:

Oct. 16, 2017

Measles virus encoding a tumor antigen

Applicant:

Ruprecht-karls-universitat Heidelberg, Heidelberg, DE;

Inventors:

Elena Czink, Heidelberg, DE;

Christine Engeland, Heidelberg, DE;

Guy Ungerechts, Heidelberg, DE;

Assignee:

RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG, Heidelberg, DE;

Attorney:

J.A. Lindeman & Co. PLLC

Primary Examiner:

James D Schultz

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/85 (2006.01); A61K 39/00 (2006.01); C12N 7/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0015 (2013.01); A61K 39/0011 (2013.01); A61K 39/00114 (2018.08); A61K 39/00117 (2018.08); A61K 39/00119 (2018.08); A61K 39/001104 (2018.08); A61K 39/001106 (2018.08); A61K 39/001109 (2018.08); A61K 39/001112 (2018.08); A61K 39/001113 (2018.08); A61K 39/001124 (2018.08); A61K 39/001129 (2018.08); A61K 39/001156 (2018.08); A61K 39/001166 (2018.08); A61K 39/001182 (2018.08); A61K 39/001186 (2018.08); A61K 39/001188 (2018.08); A61K 39/001191 (2018.08); A61K 39/001192 (2018.08); A61K 39/001193 (2018.08); A61K 39/001194 (2018.08); A61K 39/001195 (2018.08); A61K 48/005 (2013.01); A61P 35/00 (2018.01); C12N 7/00 (2013.01); A61K 2039/5256 (2013.01); C07K 14/4748 (2013.01); C12N 2760/18434 (2013.01); C12N 2760/18441 (2013.01); C12N 2760/18471 (2013.01); C12N 2799/021 (2013.01); C12N 2799/04 (2013.01);
Abstract

The present invention relates to a recombinant virus of the family Paramyxoviridae comprising an expressible polynucleotide encoding at least one of (i) a tumor antigen, (ii) a fragment of a tumor antigen, and (iii) a variant of (i) or (ii). The present invention further relates to a polynucleotide encoding said recombinant virus of the family Paramyxoviridae and to a host cell comprising said recombinant virus of the family Paramyxoviridae and/or said polynucleotide encoding said recombinant virus of the family Paramyxoviridae. Moreover, the present invention relates to a method for activating immune cells with antitumor activity in a sample comprising cancer cells and to further means, methods, and uses related to the present invention.

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