The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2022

Filed:

Aug. 25, 2017
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Charles K. F. Chan, Redwood City, CA (US);

Andrew Stephen Lee, Palo Alto, CA (US);

Michael T. Longaker, Atherton, CA (US);

Irving L. Weissman, Stanford, CA (US);

Joseph Wu, Stanford, CA (US);

Divya Nag, Palo Alto, CA (US);

Eun Young Seo, San Jose, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/35 (2015.01); A61K 35/28 (2015.01); C12N 5/0775 (2010.01); A61P 9/10 (2006.01); A61K 9/00 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 35/35 (2013.01); A61K 9/0019 (2013.01); A61K 35/28 (2013.01); A61P 9/10 (2018.01); C12N 5/0653 (2013.01); C12N 5/0667 (2013.01);
Abstract

Methods, compositions, and kits for producing functional blood vessels, and progenitors thereof are provided. Human disorders of the vascular system are treated by reconstitution of functional vessels in vivo through co-transplantation with supporting niche stromal cells for treatment of ischemic injury in the peripheral limbs and heart. The cell populations of the invention, when engrafted into a recipient, anastomose with host vasculature and regenerate functional blood vessels.


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