The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Oct. 24, 2018
Applicants:
Da Volterra, Paris, FR;
Bioaster, Lyons, FR;
Inventors:
Jean De Gunzburg, London, GB;
Jean-Denis Docquier, Sovicille, IT;
Assignees:
Da Volterra, Paris, FR;
Bioaster, Lyons, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/84 (2006.01); C12N 1/21 (2006.01); A61K 38/50 (2006.01); C12N 9/86 (2006.01); A61K 31/407 (2006.01); A61K 31/496 (2006.01); A61K 31/546 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/86 (2013.01); A61K 31/407 (2013.01); A61K 31/496 (2013.01); A61K 31/546 (2013.01); A61K 38/50 (2013.01); C12Y 305/02006 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.