The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Nov. 06, 2020
Pfizer Inc., New York, NY (US);
Andreas Maderna, San Diego, CA (US);
Chakrapani Subramanyam, South Glastonbury, CT (US);
Lawrence N. Tumey, Pawcatuck, CT (US);
Zecheng Chen, New City, NY (US);
Jeffrey M. Casavant, Franklin, CT (US);
PFIZER INC., New York, NY (US);
Abstract
The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula:F-L-T-L-Fwhere F, L, T, Land Fare as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.