The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Jul. 05, 2018
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Joseph Schlessinger, Woodbridge, CT (US);
Sangwon Lee, Branford, CT (US);
Assignee:
YALE UNIVERSITY, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/50 (2006.01); C07K 16/22 (2006.01);
U.S. Cl.
CPC ...
C07K 14/50 (2013.01); C07K 16/22 (2013.01); C07K 2317/76 (2013.01); C07K 2319/35 (2013.01);
Abstract
The present invention relates, in one aspect, to certain mutant FGF21 polypeptide constructs. In certain non-limiting embodiments, the construct binds to β-Klotho more tightly than wild-type FGF21. In certain non-limiting embodiments, the construct has a mutation in at least one residue of SEQ ID NO:3 selected from the group consisting of V188, R203, and L194. In certain non-limiting embodiments, the construct further comprises a stability enhancing domain.