The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Mar. 20, 2019
Applicant:
Aurigene Discovery Technologies Limited, Bangalore, IN;
Inventors:
Dinesh Chikkanna, Bangalore, IN;
Sunil Kumar Panigrahi, Boudh, IN;
Srinivasa Raju Sammeta, Bangalore, IN;
Wohlfahrt Gerd, Helsinki, FI;
Myllymaki Mikko, Espoo, FI;
Assignee:
AURIGENE DISCOVERY TECHNOLOGIES LIMITED, Karnataka, IN;
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/4725 (2006.01); C07D 498/08 (2006.01); A61P 35/00 (2006.01); C07D 401/06 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); A61P 35/00 (2018.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01);
Abstract
The present invention relates to the derivatives of compound of formula (I) and pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and use thereof as PRMT5 inhibitors. The compounds are useful as medicaments in the treatment of conditions where PRMT5 inhibition is desired, such as cancer, metabolic disorders, inflammation, autoimmune disease and hemoglobinopathies.