The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Jun. 01, 2020
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Chen Mao, Foster City, CA (US);
Dawen Kou, Millbrae, CA (US);
Po-Chang Chiang, South San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 9/10 (2006.01); A61K 9/20 (2006.01); C07D 487/04 (2006.01); A61K 9/14 (2006.01); C07C 309/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 9/10 (2013.01); A61K 9/146 (2013.01); A61K 9/2013 (2013.01); A61K 31/4985 (2013.01); C07C 309/04 (2013.01); C07B 2200/13 (2013.01);
Abstract
The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound (S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton's tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.