The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 21, 2022

Filed:

Feb. 26, 2019
Applicant:

Dart Neuroscience, Llc, Dallas, TX (US);

Inventors:

Jillian Basinger Thompson, San Diego, CA (US);

Brett C. Bookser, San Diego, CA (US);

Scott Burley, Oceanside, CA (US);

Pablo Garcia-Reynaga, San Diego, CA (US);

Andrew Hudson, San Diego, CA (US);

Marco Peters, Fallbrook, CA (US);

Benjamin Pratt, Encinitas, CA (US);

Aaron Thompson, San Diego, CA (US);

Joe Tran, San Marcos, CA (US);

Lino Valdez, San Diego, CA (US);

Assignee:

Dart NeuroScience, LLC, Dallas, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/12 (2006.01); C07D 213/38 (2006.01); C07C 255/46 (2006.01); C07D 211/76 (2006.01); C07D 207/14 (2006.01); C07D 207/273 (2006.01); C07C 211/40 (2006.01); C07D 211/58 (2006.01); C07D 309/14 (2006.01); C07D 401/12 (2006.01); C07C 237/24 (2006.01); C07D 211/96 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61P 25/28 (2018.01); C07C 211/40 (2013.01); C07C 237/24 (2013.01); C07C 255/46 (2013.01); C07D 207/14 (2013.01); C07D 207/273 (2013.01); C07D 211/58 (2013.01); C07D 211/76 (2013.01); C07D 211/96 (2013.01); C07D 213/38 (2013.01); C07D 309/14 (2013.01); C07D 401/12 (2013.01); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05);
Abstract

Substituted cyclohexyl chemical entities of Formula (I): wherein R, G, and Rhave any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.


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