The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Oct. 03, 2017
Applicant:
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Inventor:
Kurt Iver Kamrud, San Diego, CA (US);
Assignee:
JANSSEN PHARMACEUTICALS, INC., Titusville, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C12N 7/01 (2006.01); C12N 5/10 (2006.01); A61K 48/00 (2006.01); C12N 15/67 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); C12N 15/67 (2013.01); C12N 15/86 (2013.01); A61K 2039/53 (2013.01); C12N 2770/36143 (2013.01);
Abstract
The present disclosure generally relates to viral-based expression systems suitable for the production of molecules of interest. The disclosure relates to nucleic acid constructs, such as expression vectors, containing a modified replicon RNA which includes a modified 5'-unstranslated region (5′-UTR) and, optionally, at least some of its original viral sequence encoding structural proteins having been deleted. Also disclosed are methods for producing polypeptides of interest.