The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 21, 2022

Filed:

Nov. 06, 2018
Applicants:

Norwegian University of Science and Technology (Ntnu), Trondheim, NO;

University of Connecticut, Farmington, CT (US);

Inventors:

Justin Cotney, Guilford, CT (US);

Clifford Kentros, Malvik, NO;

Stefan Blankvoort, Trondheim, NO;

Rajeevkumar Raveendran Nair, Trondheim, NO;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 7/00 (2006.01); C12N 15/113 (2010.01); A61P 25/28 (2006.01); C12N 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0041 (2013.01); A61K 48/0058 (2013.01); A61P 25/28 (2018.01); C12N 5/10 (2013.01); C12N 7/00 (2013.01); C12N 15/113 (2013.01); C12N 2310/122 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/531 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01);
Abstract

A delivery vehicle which comprises a nucleic acid construct, wherein the nucleic acid construct comprises (i) an enhancer which specifically drives gene expression in cells of the entorhinal cortex (ii) a promoter; and (iii) a therapeutic gene, wherein said enhancer, promoter and therapeutic gene are operatively linked, said enhancer and therapeutic gene are heterologous, and said delivery vehicle is suitable for delivery of the nucleic acid construct to the brain of a mammal.


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