The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
Dec. 06, 2019
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Matthew J. Marton, Whitehouse Station, NJ (US);
Yair Benita, Tel Aviv, IL;
Assignee:
MERCK SHARP & DOHME CORP., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); A61K 31/00 (2006.01); A61P 35/00 (2006.01); A61K 31/519 (2006.01); A61K 31/555 (2006.01); A61K 31/513 (2006.01); A61K 31/704 (2006.01); A61K 45/06 (2006.01); A61K 31/7048 (2006.01); A61K 31/4745 (2006.01); A61K 31/4188 (2006.01); A61K 31/7068 (2006.01); A61K 31/407 (2006.01); A61K 31/337 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/337 (2013.01); A61K 31/407 (2013.01); A61K 31/4188 (2013.01); A61K 31/4745 (2013.01); A61K 31/513 (2013.01); A61K 31/555 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present invention relates generally to the use of gene mutations, whose presence or absence are useful for predicting a patient's response to treatment with an anti-proliferative agent, in particular a WEE1 inhibitor. The presence or absence of a mutation to the TP53 gene, can be used to predict response to treatment with a WEE1 inhibitor in a patient presenting with a cancerous condition.