The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2022
Filed:
May. 19, 2017
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Universite DE Lille, Lille, FR;
Institut Pasteur DE Lille, Lille, FR;
Centre National DE LA Recherche Scientifique—cnrs-, Paris, FR;
Mathias Chamaillard, Lille, FR;
INSERM (INSTITUT NATION DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), Paris, FR;
UNIVERSITE DE LILLE, Lille, FR;
INSTITUT PASTEUR DE LILLE, Lille, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CRNS—, Paris, FR;
Abstract
The present invention relates to the treatment of microbiome dysregulations. Said dysregulations may subsequently contribute to the development of several chronic diseases. Thus characterization of new post-biotic compounds inducing beneficial changes on host-microbiota interactions may be highly desirable. The inventors showed that Nlrp6 diurnally coordinates cyclical adaptation of the gut microbiota diversity to epithelial plasticity in response to a treatment with a Csnk2 inhibitor. The invention therefore relates to an inhibitor of Csnk2, for use in the treatment of microbiome dysregulations notably associated with circadian clock disruption. Said inhibitor may be selected among chemically synthesized or natural selective Csnk2 inhibitors such as flavones.