The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2022
Filed:
Aug. 04, 2021
Color Health, Inc., Burlingame, CA (US);
Ryan Barrett, San Francisco, CA (US);
Nishant Bhat, San Francisco, CA (US);
Huy Hong, Palo Alto, CA (US);
Katsuya Noguchi, San Francisco, CA (US);
Wendy McKennon, San Francisco, CA (US);
Krishna Pant, San Jose, CA (US);
Taylor Sittler, San Francisco, CA (US);
Othman Laraki, Atherton, CA (US);
Elad Gil, San Francisco, CA (US);
Color Health, Inc., Burlingame, CA (US);
Abstract
Techniques are provided for detecting copy number variations. Each sequence read of a set of sequence reads is aligned with a portion of a reference sequence. A coverage vector is generated that includes a plurality of elements, each element in the plurality of elements indicating a number of the set of sequence reads that were aligned to a particular position within the reference sequence. A normalization vector is accessed that was generated based on performance of a component analysis on a set of other coverage vectors corresponding to a set of other subjects. An adjusted coverage vector is generated using the coverage vector and normalization vector. One or more subject-specific normalization values are generated based on the coverage vector. One or more copy number variations are identified that corresponding to the sample using the adjusted coverage vector and the subject-specific normalization values.