The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 2022

Filed:

Dec. 04, 2018
Applicants:

Trustees of Boston University, Boston, MA (US);

L'université DE Bordeaux, Bordeaux, FR;

L'institut Polytechnique DE Bordeaux, Talence, FR;

Centre National DE LA Recherche Scientifique, Paris, FR;

Inventors:

James Galagan, Needham, MA (US);

Allison Dennis, Auburndale, MA (US);

Catherine Klapperich, Brookline, MA (US);

Mark Grinstaff, Brookline, MA (US);

Thuy Nguyen, Brighton, MA (US);

R. Baer, Boston, MA (US);

Uros Kuzmanovic, Boston, MA (US);

Marjon Zamani, Allston, MA (US);

Mingfu Chen, Boston, MA (US);

Margaret Chern, Brookline, MA (US);

Chloe Grazon, Boston, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/74 (2006.01); C07K 14/245 (2006.01); G01N 33/566 (2006.01); G01N 33/542 (2006.01); C07K 14/195 (2006.01); C12N 9/00 (2006.01); C07K 14/34 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
G01N 33/74 (2013.01); C07K 14/195 (2013.01); C07K 14/245 (2013.01); C07K 14/34 (2013.01); C12N 9/22 (2013.01); C12N 9/93 (2013.01); G01N 33/542 (2013.01); G01N 33/566 (2013.01); C07K 2319/20 (2013.01); C07K 2319/21 (2013.01); C07K 2319/60 (2013.01);
Abstract

Described herein are methods, compositions and processes related to a microbial-based biosensor system for the detection of small molecules and analytes based on an analyte-responsive transcription factor-DNA binding mechanism with either a ratiometric fluorescent output through Förster resonance energy transfer (FRET) or a redox sensor output for the quantification of the target analyte with high sensitivity.


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