The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2022
Filed:
Jan. 28, 2020
Forschungszentrum Borstel Leibniz Lungenzentrum, Borstel, DE;
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Christian Alexander, Borstel, DE;
Sven Deutschmann, Weilheim, DE;
Pierre Lang, Blotzheim, FR;
Friedrich Von Wintzingerode, Penzberg, DE;
Ulrich Zaehringer, Ahrensburg, DE;
Forschungszentrum Borstel Leibniz Lungenzentrum, Borstel, DE;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
Herein is reported a method for determining bacterial endotoxin at low concentrations in a sample of an antibody (that has been produced using bacterial cells) comprising the following steps in the following order: i) adding magnesium ions to the sample, ii) diluting the sample, iii) dialyzing the sample having a pH-value of 5.7-8.0 against an endotoxin-flee aqueous solution, and iv) determining bacterial endotoxin in the sample using a bacterial endotoxin test, particularly theamoebocyte lysate assay.