The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2022
Filed:
Apr. 17, 2018
Applicants:
The Regents of the University of California, Oakland, CA (US);
Marc O. Anderson, San Francisco, CA (US);
Inventors:
Marc O. Anderson, San Francisco, CA (US);
Alan S. Verkman, San Francisco, CA (US);
Puay Wah Phuan, San Francisco, CA (US);
Assignees:
The Regents of the University of California, Oakland, CA (US);
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 333/80 (2006.01); A61P 9/12 (2006.01); A61P 35/00 (2006.01); C07D 333/68 (2006.01); C07D 333/78 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 333/80 (2013.01); A61P 9/12 (2018.01); A61P 35/00 (2018.01); C07D 333/68 (2013.01); C07D 333/78 (2013.01); C07D 495/04 (2013.01);
Abstract
Provided herein are inhibitors of transmembrane protein 16A (TMEM 16A), a Ca-activated CI″ channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment or management of disorders of epithelial fluid and mucus secretion, hypertension, some cancers, pain, and other diseases.