logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11358921 B1

PDFFull Text
Date of Patent:
Jun. 14, 2022

Filed:

Mar. 19, 2019

Fused cyclooctyne compounds and their use in metal-free click reactions

Applicant:

Synaffix B.v., Oss, NL;

Inventors:

Floris Louis Van Delft, Nijmegen, NL;

Floris Petrus Johannes Theodorus Rutjes, Wijchen, NL;

Frederik Jan Dommerholt, Beuningen, NL;

Assignee:

SYNAFFIX B.V., Oss, NL;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Irina Neagu

Int. Cl.
CPC ...
C07D 249/16 (2006.01); C07D 261/20 (2006.01); A61K 47/54 (2017.01); A61K 49/00 (2006.01); G01N 33/58 (2006.01); G01N 33/532 (2006.01); C07C 33/16 (2006.01); C07C 29/147 (2006.01); C07C 29/58 (2006.01); C07C 29/62 (2006.01); C07C 67/347 (2006.01); C07C 271/12 (2006.01); C07C 62/30 (2006.01); C07C 269/06 (2006.01); C07C 271/20 (2006.01); C07D 311/82 (2006.01); C07D 495/04 (2006.01); C07K 14/47 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
C07C 33/16 (2013.01); A61K 47/54 (2017.08); A61K 49/0052 (2013.01); C07C 29/147 (2013.01); C07C 29/58 (2013.01); C07C 29/62 (2013.01); C07C 62/30 (2013.01); C07C 67/347 (2013.01); C07C 269/06 (2013.01); C07C 271/12 (2013.01); C07C 271/20 (2013.01); C07D 311/82 (2013.01); C07D 495/04 (2013.01); C07K 14/47 (2013.01); G01N 21/6428 (2013.01); G01N 33/532 (2013.01); G01N 33/582 (2013.01); G01N 33/585 (2013.01); C07C 2602/24 (2017.05); G01N 2021/6439 (2013.01);
Abstract

The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.

Find Patent Forward Citations

Loading…