The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2022
Filed:
Aug. 29, 2018
Applicant:
Km Biologics Co., Ltd., Kumamoto, JP;
Inventors:
Hiroaki Mori, Kumamoto, JP;
Tomohiro Nishimura, Kumamoto, JP;
Hiroyuki Shimizu, Ageo, JP;
Akihiro Koube, Kikuyo-machi, JP;
Takahiro Katayama, Kawasaki, JP;
Assignee:
KM BIOLOGICS CO., LTD., Kumamoto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/245 (2006.01); A61P 31/22 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
A61K 39/245 (2013.01); A61P 31/22 (2018.01); C07K 14/005 (2013.01);
Abstract
The modified HSV gD protein of the present invention is a modified protein of a herpes simplex virus (HSV) envelope glycoprotein D (gD), wherein the modified HSV gD protein is derived from a wild-type HSV gD by modification of at least one of B cell epitopes having low or no neutralizing antibody-inducing activity compared to a B cell epitope present in a receptor-binding domain (RBD) (decotopes) in the ectodomain of the wild-type HSV gD, so that the modified epitope does not function as an epitope.