The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2022
Filed:
Jan. 15, 2020
Applicant:
Takeda Pharmaceutical Company Limited, Osaka, JP;
Inventors:
Ann Barbier, Lexington, MA (US);
Thomas Mccauley, Cambridge, MA (US);
Charles W. Richard, III, Carlisle, MA (US);
Assignee:
Takeda Pharmaceutical Company Limited, Osaka, JP;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A61K 38/46 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); A61K 9/0019 (2013.01); A61K 9/0085 (2013.01); A61K 38/46 (2013.01); C12N 9/16 (2013.01); C12Y 301/06013 (2013.01);
Abstract
The present invention, provides a method of treating cognitive impairment of Hunter syndrome. Among other things, the present invention provides a method comprising a step of administering intrathecally to a subject in need of treatment a recombinant iduronate-2-sulfatase (I2S) enzyme at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce declining of one or more cognitive, adaptive, motor, and/or executive functions relative to a control.