The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 07, 2022

Filed:

Mar. 15, 2019
Applicants:

Vib Vzw, Ghent, BE;

Vrije Universiteit Brussel, Brussels, BE;

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Jan Steyaert, Beersel, BE;

Toon Laeremans, Dworp, BE;

Els Pardon, Lubbeek, BE;

Brian Kobilka, Palo Alto, CA (US);

Aashish Manglik, Menlo Park, CA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); C07K 14/705 (2013.01); C07K 14/723 (2013.01); G01N 33/5041 (2013.01); G01N 33/6854 (2013.01); C07K 2317/22 (2013.01); C07K 2317/33 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); G01N 2333/726 (2013.01);
Abstract

Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.


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