The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2022
Filed:
May. 09, 2017
Applicant:
Albert Einstein College of Medicine, Bronx, NY (US);
Inventors:
Jonathan R. Lai, Dobbs Ferry, NY (US);
Steven Almo, Pelham, NY (US);
Nina Liu, Larchmont, NY (US);
Julia Frei, New York, NY (US);
Assignee:
ALBERT EINSTEIN COLLEGE OF MEDICINE, Bronx, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61P 35/00 (2006.01); A61K 38/16 (2006.01); C07K 14/735 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); A61P 31/00 (2006.01); A61K 38/17 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70535 (2013.01); A61K 38/16 (2013.01); A61K 38/1774 (2013.01); A61P 31/00 (2018.01); A61P 35/00 (2018.01); C07K 14/47 (2013.01); C07K 14/705 (2013.01); C07K 14/70503 (2013.01); C07K 14/70521 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD-L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.