The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2022
Filed:
Apr. 03, 2019
Applicant:
Duke University, Durham, NC (US);
Inventor:
Christopher David Lascola, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/055 (2006.01); A61K 49/10 (2006.01); A61K 49/08 (2006.01); A61K 47/54 (2017.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 31/663 (2006.01); A61K 31/675 (2006.01); A61K 49/06 (2006.01);
U.S. Cl.
CPC ...
A61K 49/103 (2013.01); A61K 9/0019 (2013.01); A61K 31/663 (2013.01); A61K 31/675 (2013.01); A61K 47/548 (2017.08); A61K 49/085 (2013.01); A61K 49/101 (2013.01); A61P 35/00 (2018.01); A61K 49/06 (2013.01); A61K 49/106 (2013.01);
Abstract
Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.