The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2022
Filed:
Aug. 03, 2020
Bioversys Ag, Basel, CH;
Glenn E. Dale, Basel, CH;
Sergio Lociuro, Basel, CH;
Christian Kemmer, Riehen, CH;
Vincent Trebosc, Rixheim, FR;
Marc Gitzinger, Laufenburg, CH;
BIOVERSYS AG, Basel, CH;
Abstract
The invention provides systems and methods for increased clinical efficacy of rifabutin against. The invention takes advantage of the discovery of a ferric-coprogen (FhuE) receptor that is responsible for the uptake of rifabutin intocells. Methods preferably include obtaining a sample from a patient suspected of having an infection; performing a test on the sample to identify an infection ofin the patient; and providing a formulation of rifabutin for treating the patient that, when administered to the patient, maximizes a resultant AUC and/or C. The method may include administering the formulation of rifabutin to the patient. Preferably the formulation is delivered to the patient, e.g., by intravenous injection and results in a Cis that greater than about 2 mg/L and optionally less than about 50 mg/L.