The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2022
Filed:
Apr. 16, 2020
Applicant:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Inventors:
Mark R. Kelley, Zionsville, IN (US);
Jill Fehrenbacher, Indianapolis, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Bloomington, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/192 (2006.01); A61K 45/06 (2006.01); A61K 31/165 (2006.01); A61K 31/201 (2006.01); A61K 31/555 (2006.01); A61K 31/282 (2006.01); A61K 33/243 (2019.01); A61P 25/02 (2006.01); A61N 5/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/192 (2013.01); A61K 31/165 (2013.01); A61K 31/201 (2013.01); A61K 31/555 (2013.01); A61K 33/243 (2019.01); A61K 45/06 (2013.01); A61N 5/00 (2013.01); A61P 25/02 (2018.01); A61K 31/282 (2013.01);
Abstract
Methods of reducing neuronal sensitivity, thereby reducing inflammation and chronic pain, in subjects having diabetes are disclosed herein. Particularly disclosed are methods of administrating the apurinic/apyrimidinic endonuclease 1 redox factor 1 (APE 1/Ref-1) inhibitor, APX3330, to enhance the DNA base excision repair (BER) pathway, thereby reducing neuronal sensitivity to inflammatory mediators and alleviating inflammatory or chronic pain.