The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2022
Filed:
Feb. 21, 2017
Poly(n-butyl cyanoacrylate) nanoparticle with dual modifications, preparation method and use thereof
Applicant:
Xuanwu Hospital of Capital Medical University, Beijing, CN;
Assignee:
Xuanwu Hospital of Capital Medical University, Beijing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 47/32 (2006.01); A61K 9/51 (2006.01); A61K 49/00 (2006.01); A61P 25/00 (2006.01); A61K 31/337 (2006.01); A61K 47/42 (2017.01); A61K 47/34 (2017.01);
U.S. Cl.
CPC ...
A61K 9/5138 (2013.01); A61K 9/14 (2013.01); A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 9/5192 (2013.01); A61K 31/337 (2013.01); A61K 49/0039 (2013.01); A61K 49/0093 (2013.01); A61P 25/00 (2018.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01);
Abstract
The invention relates to a poly(n-butyl cyanoacrylate) nanoparticle with dual modifications, a drug delivery system comprising the nanoparticle, and a method for preparing the nanoparticle or the drug delivery system. The nanoparticle is modified with a first modifier and a second modifier on the surface, the first modifier is a hydrophilic polymer, and the second modifier is an amino acid and/or a lipid. The invention further relates to a use of the nanoparticle in promoting drug penetration across the blood brain barrier in a subject.