The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2022
Filed:
Apr. 17, 2018
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
Laura Ranum, Gainesville, FL (US);
Tao Zu, Gainesville, FL (US);
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 35/761 (2015.01); A61K 38/45 (2006.01); C07K 14/47 (2006.01); C12N 15/66 (2006.01);
U.S. Cl.
CPC ...
C12N 15/102 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 35/761 (2013.01); A61K 38/45 (2013.01); C07K 14/47 (2013.01); C12N 15/66 (2013.01); C12N 2750/14143 (2013.01); C12Y 207/01037 (2013.01);
Abstract
Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by the disclosure are useful for treating diseases associated with RAN protein translation, such as certain neurodegenerative diseases.