The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2022
Filed:
Nov. 17, 2017
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C12N 5/071 (2010.01); C07K 14/705 (2006.01); C12N 5/0789 (2010.01); C12N 5/0783 (2010.01); C07K 14/47 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 5/069 (2013.01); A61K 35/17 (2013.01); C07K 14/4702 (2013.01); C07K 14/70503 (2013.01); C12N 5/0636 (2013.01); C12N 5/0647 (2013.01); A61K 2035/124 (2013.01); C12N 2501/42 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/727 (2013.01); C12N 2506/02 (2013.01); C12N 2506/28 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK and NOTCH signaling at the mesodermal stage of differentiation.