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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11345746 B1

PDFFull Text
Date of Patent:
May. 31, 2022

Filed:

Dec. 14, 2016

Fully human antibody specifically inhibiting connexin 26

Applicant:

Shanghaitech University, Shanghai, CN;

Inventors:

Zhihu Qu, Shanghai, CN;

Guang Yang, Shanghai, CN;

Fabio Mammano, Padua, IT;

Francesco Zonta, Shanghai, CN;

Assignee:

SHANGHAITECH UNIVERSITY, Shanghai, CN;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Joanne Hama

Assistant Examiner:

Jon M Lockard

Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/51 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01);
Abstract

The present invention provides a fully human antibody specifically inhibiting Connexin 26, characterized in that it is a recombinant immunoglobulin having the structure of scFv-Fc, wherein scFv refers to a single-chain antibody comprising a heavy chain variable region and a light chain variable region, the amino acid sequence of the heavy chain variable region is SEQ ID NO: 1, the amino acid sequence of the light chain variable region is SEQ ID NO: 2, and Fc refers to constant region. The present invention uses the first 41-56 amino acid sequence of extracellular region of Connexin26 as an antigen, the sequence thereof is KEVWGDEQADFVCNTL. Through the biochemical analysis and immunofluorescence identification of the antibody obtained by single-chain antibody phage display library and screening technology, it was confirmed that the antibody provided by the present invention could specifically recognize Connexin 26 and inhibit its hemichannel activity. Animal experiments show that this antibody significantly inhibits the hemichannel activity of mouse cochlear tissue sections. Therefore, the antibody can be used in the treatment of Connexin mutation associated diseases.

Find Patent Forward Citations

Qu, Zhihu. (2022). Fully human antibody specifically inhibiting connexin 26 (U.S. Patent No. 11345746). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11345746

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