The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2022
Filed:
Sep. 16, 2020
Applicant:
Research Foundation of the City University of New York, New York, NY (US);
Inventors:
Guillermo Gerona-Navarro, New York, NY (US);
Gan Zhang, Brooklyn, NY (US);
Flavia Barragan, Berlin, DE;
Assignee:
Research Foundation of the City University of New York, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01);
Abstract
This disclosure describes three novel bisthioether stapled peptides as allosteric inhibitors of Polycomb Repressive Complex 2 (PRC2) catalytic function with demonstrated cell permeability, potent activity in physiological conditions, and strong antiproliferative effects on cancer cells. These inhibitors target, for the first time, two protein interfaces in PRC2 that are crucial for its proper assembling and thus for its histone methyltransferase activity.