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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11345724 B1

PDFFull Text
Date of Patent:
May. 31, 2022

Filed:

Jun. 06, 2017

Proteasome inhibitors

Applicant:

Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v., Munich, DE;

Inventors:

Ashwin Chari, Göttingen, DE;

Holger Stark, Waake, DE;

Jil Schrader, Göttingen, DE;

Fabian Henneberg, Göttingen, DE;

Assignee:

Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Munich, DE;

Attorneys:

Foley Hoag LLP

David P. Halstead

Lawrence P. Tardibono

Primary Examiner:

Jeffrey E Russel

Int. Cl.
CPC ...
A61K 38/06 (2006.01); C07K 5/083 (2006.01); C07K 5/087 (2006.01); C07K 5/062 (2006.01); C07K 5/02 (2006.01); A61K 38/00 (2006.01); A61K 38/03 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06069 (2013.01); A61K 38/005 (2013.01); A61K 38/03 (2013.01); A61K 38/06 (2013.01); C07K 5/0202 (2013.01); C07K 5/081 (2013.01); C07K 5/0806 (2013.01); C07K 5/0808 (2013.01); C07K 5/0812 (2013.01);
Abstract

The present invention relates to a compound of formula (I), wherein X is C═O, C═S or B—OH; Y is an electrophile and Z is a leaving group, or Y═Z is an electrophile; Rcomprises or consists of (a) (i) a first group binding to a proteolytic site of a proteasome, the first group being bound to X; and (ii) optionally a second group enhancing delivery; or (b) a group binding between subunits β1 and β2 of a proteasome; Rand Rare independently selected from H, methyl, methoxy, ethyl, ethenyl, ethynyl and cyano, wherein methyl and ethyl may be substituted with OH or halogen.

Find Patent Forward Citations

Chari, Ashwin. (2022). Proteasome inhibitors (U.S. Patent No. 11345724). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11345724

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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