The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2022
Filed:
Jan. 08, 2019
Jiangsu Hengrui Medicine Co., Ltd., Jiangsu, CN;
Wenhai Li, Lianyungang, CN;
Yingjie Zhang, Lianyungang, CN;
JIANGSU HENGRUI MEDICINE CO., LTD., Jiangsu, CN;
Abstract
A preparation method for a compound represented by formula I or a pharmaceutically acceptable salt thereof, The method includes a step of reacting a compound represented by formula II with an inorganic or organic acid selected from the group consisting of hydrochloric acid, phosphoric acid and maleic acid to provide a compound represented by formula II' In the above formulas II and II′, Rmay be trifluoromethyl; and X may be hydrochloric acid, phosphoric acid, or maleic acid. The method also includes a step of reacting the compound represented by formula II′ with a compound represented by formula IV: to provide the compound represented by formula I, wherein Ris selected from hydroxyl, halogen or alkoxy.