The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 31, 2022

Filed:

Mar. 01, 2018
Applicants:

Charles Jeffrey Brinker, Albuquerque, NM (US);

Kimberly Butler, Albuquerque, NM (US);

Paul N. Durfee, Albuquerque, NM (US);

Inventors:

Charles Jeffrey Brinker, Albuquerque, NM (US);

Kimberly Butler, Albuquerque, NM (US);

Paul N. Durfee, Albuquerque, NM (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61P 35/00 (2006.01); A61K 39/395 (2006.01); A61K 47/69 (2017.01); A61P 35/02 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6915 (2017.08); A61K 47/6913 (2017.08); A61K 47/6923 (2017.08); A61P 35/02 (2018.01); C07K 16/2803 (2013.01); C07K 16/3061 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01);
Abstract

In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.


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