The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2022

Filed:

Sep. 06, 2019
Applicants:

Critical Care Diagnostics, Inc., San Diego, CA (US);

Cardiac Pacemakers, Inc., Saint Paul, MN (US);

Inventors:

James V. Snider, San Diego, CA (US);

Timothy Edward Meyer, North Oaks, MN (US);

Craig Michael Stolen, New Brighton, MN (US);

Robert W. Gerwien, Newington, CT (US);

Assignees:

Critical Care Diagnostics, Inc., San Diego, CA (US);

Cardiac Pacemakers, Inc., St. Paul, MN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); A61B 5/00 (2006.01); A61N 1/362 (2006.01); A61N 1/39 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6887 (2013.01); A61B 5/7275 (2013.01); A61N 1/3627 (2013.01); G01N 33/6893 (2013.01); A61N 1/3956 (2013.01); G01N 2333/7155 (2013.01); G01N 2800/325 (2013.01); G01N 2800/326 (2013.01); G01N 2800/50 (2013.01);
Abstract

Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.


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