The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Mar. 14, 2017
Applicant:
Biogen International Neuroscience Gmbh, Baar, CH;
Inventors:
Carl Co, Somerville, MA (US);
Allyson Masci, Somerville, MA (US);
Svetlana Bergelson, Newton, MA (US);
Assignee:
Biogen International Neuroscience GmbH, Baar, CH;
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/569 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56972 (2013.01); G01N 33/5008 (2013.01); G01N 33/5032 (2013.01); G01N 33/5055 (2013.01); G01N 33/5094 (2013.01); G01N 33/56966 (2013.01);
Abstract
The present disclosure provides methods of assaying for antibody-dependent cell-mediated phagocytosis (ADCP). In some embodiments, the methods include monomerizing and labeling a protein, contacting the protein with a protein-specific antibody to form an antibody-protein complex, contacting the antibody-protein complex with a phagocytic cell to permit phagocytosis, and assessing the amount of internalized fluorescence.