The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Feb. 15, 2013
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Jeffrey Matthew Nivala, Santa Cruz, CA (US);
Douglas Benjamin Marks, Santa Cruz, CA (US);
Mark Albert Akeson, Santa Cruz, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/48 (2006.01); B82Y 15/00 (2011.01); C12M 1/00 (2006.01); G01N 33/543 (2006.01); G01N 33/487 (2006.01);
U.S. Cl.
CPC ...
C12M 47/06 (2013.01); C12Q 1/48 (2013.01); G01N 33/54366 (2013.01); B82Y 15/00 (2013.01); G01N 33/48721 (2013.01);
Abstract
Described herein is a device and method for translocating a protein through a nanopore and monitoring electronic changes caused by different amino acids in the protein. The device comprises a nanopore in a membrane, an amplifier for providing a voltage between theside and trans side of the membrane, and an NTP driven unfoldase which processed the protein to be translocated. The exemplified unfoldase is the ClpX unfoldase from