The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2022

Filed:

Jul. 13, 2018
Applicant:

Industry-university Cooperation Foundation Hanyang University, Seoul, KR;

Inventors:

Sang-Hun Lee, Seoul, KR;

Yong Hee Rhee, Seoul, KR;

Chang-Hwan Park, Seoul, KR;

Mi-Yoon Chang, Gyeonggi-do, KR;

Yanuar Alan Sulistio, Seoul, KR;

Ji Yun Ko, Gyeonggi-do, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 48/00 (2006.01); A61K 35/30 (2015.01); A61K 35/761 (2015.01); C12N 15/861 (2006.01); C12N 5/077 (2010.01); C12N 5/0775 (2010.01); A61K 35/28 (2015.01); A61K 35/33 (2015.01); A61K 35/34 (2015.01); C12N 5/0797 (2010.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 35/28 (2013.01); A61K 35/30 (2013.01); A61K 35/33 (2013.01); A61K 35/34 (2013.01); A61K 35/761 (2013.01); A61K 48/00 (2013.01); C12N 5/0623 (2013.01); C12N 5/0654 (2013.01); C12N 5/0656 (2013.01); C12N 5/0658 (2013.01); C12N 5/0662 (2013.01); C12N 5/0663 (2013.01); C12N 15/861 (2013.01); C12N 2501/608 (2013.01); C12N 2506/1353 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present invention relates to a cell therapeutic agent comprising a stem cell expressing Lin28, a pharmaceutical composition comprising a stem cell expressing Lin28 for the prevention or treatment of a neurological disorder, a bone disorder, a muscular system disorder, an epithelium-related disorder or a blood-related disorder, and a method for treating a neurological disorder, a bone disorder, a muscular system disorder, an epithelium-related disorder or a blood-related disorder using the composition. A stem cell excellent in terms of differentiation potency to various tissue cells and renewal ability can be prepared by introducing Lin28, which regulates an embryonic development procedure, or a vector expressing Lin28 during stem cell culturing, and by culturing the cell.


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