The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Jul. 27, 2020
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventor:
Simon Breitler, Basel, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 5/06 (2006.01); C07H 15/08 (2006.01); C07D 207/46 (2006.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07D 207/46 (2013.01); C07H 1/00 (2013.01); C07H 5/06 (2013.01); C07H 15/08 (2013.01);
Abstract
The invention comprises a process for the preparation of GalNAc oligonucleotide conjugates which comprises the coupling of a GalNAc cluster compound of the formula or corresponding salts, enantiomers and/or a stereoisomer thereof, with an oligonucleotide in the presence of an O-dicarboximidouronium salt as coupling agent.