The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2022

Filed:

Aug. 06, 2019
Applicant:

Inorbit Therapeutics Ab, Billdal, SE;

Inventors:

Rajiv Sharma, Fremont, CA (US);

Lambertus Benthem, Billdal, SE;

Robert Judkins, Mölndal, SE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 261/08 (2006.01); C07D 451/06 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
C07D 451/06 (2013.01); C07D 261/08 (2013.01); C07D 413/12 (2013.01);
Abstract

Provided are compounds that can act as a modulator of a farnesoid X receptor (FXR) and that can be useful in the treatment of diseases and/or disorders associated with the FXR such as bile acid related disorders, metabolic syndrome, type-2-diabetes, hyperlipidemia, hypertriglyceridemia, primary biliary cirrhosis (PBC), fatty liver disease, nonalcoholic steatohepatitis (NASH), inflammatory autoimmune diseases, Crohn's disease, multiple sclerosis, atherosclerosis, kidney disorders (including chronic kidney disease), hepatic and colon cancers, and other disorders. The compounds are in the class of sulfinic acid compounds and can be an enantiomer, stereoisomer, tautomer, solvate, hydrate, prodrug, metabolite, or pharmaceutically acceptable salt thereof. Compositions including such compounds are also provided along with methods for preparing compounds of the present invention and their use.


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