The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Mar. 16, 2020
Applicant:
Pmv Pharmaceuticals, Inc., Cranbury, NJ (US);
Inventors:
Binh Vu, North Caldwell, NJ (US);
Romyr Dominique, East Brunswick, NJ (US);
Hongju Li, Edison, NJ (US);
Assignee:
PMV Pharmaceuticals, Inc., Cranbury, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 471/10 (2006.01); A61K 31/4045 (2006.01); A61P 11/00 (2006.01); A61P 15/00 (2006.01); A61K 31/454 (2006.01); A61P 43/00 (2006.01); C07D 209/14 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/4045 (2013.01); A61K 31/454 (2013.01); A61P 11/00 (2018.01); A61P 15/00 (2018.01); A61P 43/00 (2018.01); C07D 209/14 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 491/107 (2013.01);
Abstract
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.