The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Oct. 25, 2019
Mandana Veiseh, Piedmont, CA (US);
Pirooz Parvarandeh, Los Altos, CA (US);
S. Bahram Bahrami, Piedmont, CA (US);
Oliver Peter King-smith, Aptos, CA (US);
Todd S. Rutherford, Wyoming, OH (US);
Aaron Peter Schellenberg, Santa Cruz, CA (US);
Timothy Scott Edward Hiller, Ontario, CA;
Mandana Veiseh, Piedmont, CA (US);
Pirooz Parvarandeh, Los Altos, CA (US);
S. Bahram Bahrami, Piedmont, CA (US);
Oliver Peter King-Smith, Aptos, CA (US);
Todd S. Rutherford, Wyoming, OH (US);
Aaron Peter Schellenberg, Santa Cruz, CA (US);
Timothy Scott Edward Hiller, Ontario, CA;
Polybiomics, Inc., Piedmont, CA (US);
Abstract
Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.