The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2022
Filed:
Jan. 28, 2019
Applicant:
Duke University, Durham, NC (US);
Inventors:
Jacob P. R. Jacobsen, Durham, NC (US);
Marc G. Caron, Hillsborough, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/405 (2006.01); A61K 31/135 (2006.01); A61K 31/138 (2006.01); A61K 31/15 (2006.01); A61K 31/198 (2006.01); A61K 31/343 (2006.01); A61K 31/4406 (2006.01); A61K 31/4525 (2006.01); A61K 31/454 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
A61K 31/405 (2013.01); A61K 31/135 (2013.01); A61K 31/138 (2013.01); A61K 31/15 (2013.01); A61K 31/198 (2013.01); A61K 31/343 (2013.01); A61K 31/4406 (2013.01); A61K 31/454 (2013.01); A61K 31/4525 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01);
Abstract
Provided are methods of enhancing bioavailability of enterally administered 5-hydroxytryptophan (5-HTP) in a subject in need thereof, said method comprising enterally co-administering low-dose carbidopa with said 5-HTP, as well as pharmaceutical formulations useful for the same. In some embodiments, the 5-HTP and/or low-dose carbidopa are provided as slow-release formulation(s).